10/10/06

 

                                                                    

 

“Life is but a series of preludes to an unknown song
whose first notes are tolled by death. “

 

“I love life, and I want to live,
to glory in the sunshine, and revel in the rain,
to enjoy wandering in the dark, and stumbling into light.

       

On Brain-Mind Phenomena

 

The understanding of natural phenomena and the origin and mystery of life has been an ageless human concern. Many millennia ago, long before written historic records and language, the human species evolved, survived natural catastrophes, and formed a minimal social life by communicating with one another via grunts and signs. In Western Europe, Asia and China, a social life existed within disparate familial warring ‘national’ groups. It was not until 1650 AD that in Great Britain Isaac Newton a man of genius developed a unique ‘scientific’ ability to conceptualize and analyze with mathematical accuracy many natural phenomena. These scientific abilities spawned technological inventions with deep impact on the quality of human life. But efforts to learn and explain basic human behavior did not achieve a level of success comparable to that in the sciences. Ideas that worked so well in solving problems in “science areas” were not readily adaptable to the more difficult human problems associated with many long standing beliefs.

Human belief patterns stem from intimately related mind phenomena emanating from thought, memory, and emotion processes within a complex physical structure --the human brain. At birth our brain is almost not present. Brain growth during childhood is rapid and depends markedly on environmental exposure, particularly to parents and schools. Cerebral perceptions of external and internal sensory events, frequently lead to creative thoughts derived from memories of these events. Beliefs are derived either from experimentally verifiable thought patterns or from diverse spiritual thinking, both of which have a profound affect on individual and collective human behavior. Some individuals have a passion for understanding how to base their beliefs on scientific thinking while others do not abide by this requirement. Understanding our thought processes has become a focus of psycho-biological, neurological, and molecular-biological cognitive studies relating mind excitations to specific physical areas within the brain. These studies offer the hope of discovering the scientific essence of mind phenomena and of suggesting novel methods for learning to improve the quality of human life at all ages. Relatively simple meditative techniques exist for controlling thought and memory patterns which permit the learning of meaningful belief patterns.

 

Meditative control of thought and memory

 

      Awareness of one’s mental state is a quintessential requirement for improving the thinking, learning, and remembering processes that form the basis of our belief systems. Involuntary stray thoughts, however, are major impediments to willful control of awareness, and are genetically inherent in the human psyche.  They often play an important role in creative thinking but may also give rise to obsessive (semi-conscious) beliefs that cause fatigue, especially if associated with unpleasant emotional states. Meditative methods, of which there are many, afford an effective means to break the clutch of discomforting mindsets.

        Meditation comprises a mix of intentional and non-intentional mental processes that can be correlated gainfully with the natural autonomic rhythm of breathing environmental nutrients. A prime intent of meditation is to remove disconcerting mindsets by intentionally creating a relaxed state of awareness. An effective first step is to focus on the rhythm of one’s breathing, until annoying mindsets are submerged via this act of concentration. One can then shift, to simply observing one’s natural breathing. A troublesome task if the mind is being buffeted by emotionally charged feelings! Interrupting and removing discomforting mindsets can also be achieved by mantra-like (eyes closed) meditative breathing. One focuses rhythmically on an in breath and out breath for a sufficient, but not an extended time, which should permit a gradual shift into a natural breathing state of relaxed awareness. Very individual and not simple tasks, but very rewarding if successful!

On achieving (eyes open) awareness, one can progress to intentional thought tasks that set off a pleasurable meditative flow of mental activity. Meditation requires periodic practice in moving smoothly and quasi-simultaneously between rhythmic breathing and focus on pleasurable tasks. One must guard against drifting into an intensive non-flowing mental state that breeds mental fatigue. Meditation is best pursued by experimenting with either a visual or verbal flow of pleasant thought patterns. Potential creative elements may emerge if the flow evolves into a semi-intentional free wheeling sequence linked to a novel view of a task.

One of the benefits of meditation is its ability to induce sleep. One can set a natural base for transition to a sleep state, especially when tired, by concentrating solely on the rhythm of one’s natural breathing. This should permit a gradual drift into an unfocussed flow of pleasant thoughts and ultimately into a sleep state. 

The ability to control thought and memory flow and to relax into simple awareness is indicative of successful meditation. Overall, meditative exercise serves to improve mental life and, as we shall document below, can defer the aging atrophy that results from lack of mental exercise.

 

       

On Psychobiology of Thought and Memory

 

        Within the vast spectrum of life forms, the human species possesses a unique ability to think and remember. Thinking represents a unique interplay of thought and memory, captured by the aphorism: thought begets memory, and memory begets thought. Thoughts are mental processes that arise either from a complex of direct sensory perceptions or from abstract higher-level mental associations. Direct thought perceptions are associated with cerebral activity in the outer human neo-cortex and in the mid-brain, whereas abstract emotional thoughts are primarily associated with activity in the brain stem and thalamus; lower animal species do not have a neo-cortex and hence display minor mental capability.

An omni-present mix of thought and memory patterns reflects a pleasurable or troublesome state of mind, depending on one’s ability to learn how to control the flow of thinking. Controlling the flow of abstract thoughts and memories is a quintessential human asset that requires intentional mental effort. Cognitive science studies reveal that the ability to learn stems both from specific inherited areas of  brain structure as well as from environmental experience.

In our conscious state the natural autonomic flow of mental activity is frequently interspersed with a pestering miscellany of non-intentional thoughts. The latter, a rather chaotic activity, often prompted by emotional instincts, complicates volitional mind flow, engenders mental distractions, but plays an important role in human creativity. Instinctual moderated free-wheeling streams of consciousness utilize a non-intentional mix of states that link the many verbal and visual associations characteristic of creative mental states. Recent mathematical developments in chaos theory suggest that free associative thinking is a random nonlinear mental process from which self-organizing activity representative of creativity emerges.

One relevant aspect of free association is that it is less exhausting for the mind to wander freely within a forest of ever-changing thoughts than to fix on embedded thoughts. Obsessive thought fixation and resulting mental blocks are evident sources of psychobiologic mental fatigue. Psychological studies of individual and collective behavior have long been subjects of extensive efforts to document experimentally the laws that govern our behavior. In recent years these studies have begun to explore behavior in terms of the cerebral electro-chemical network being developed in the cognitive sciences. Related developments in pharmacological medications, affecting properties of the cerebral electro-chemical network, are currently sparking effective methods for modifying human behavior. 

An open psycho-biological problem revolves about measuring the physical nature of thought and memory excitations generated by structures within the brain. In physics the concept of a field suggests an interesting and metaphorically related clarification of the problem of measuring mind phenomena.  Current neuronal research on the molecular structure of the brain and its mental properties represents an important step along the road to understand how to deal with our mental beliefs about religion and ethics.

 

 

On the neuronal view of Thought and Memory

 

The human body is composed of sensory organs, a central neuronal-nervous system, and an autonomic circulatory blood system that provides nutrients essential to life. The electro-chemical neuronal network within the brain conveys sensory stimuli to a complex of cerebral cortical areas from which thought and memory excitations originate. Animal and human studies have shown that the act of learning initiates growth in the number of dendrite and synaptic constituents of cerebral neurons in areas specific to the learning process. This growth process appears to be subject to willful control. Distinctive thought and memory excitations involve a complex of distinctive neuronal areas. Since each area has a distinctive neuronal packing topography, it suggests that topography may distinguish these areas as sources and receivers of measurable mind excitations. As evidence for this suggestion, reentrant and oscillatory neuronal electric firing patterns in brain areas have been observed and correlated with memory excitations in a number of recent studies. These suggest the possibility of using ultra-sensitive (sonar or piezoelectric) spectral analysis techniques for physical measurement of the essence of thought and memory excitations. Sensory stimulated electro-chemical events are propagated throughout a neuronal network at approximately 100 meter per second speeds depending on the local topography of the network and on whether these signals are of an electrical or a diffusive biochemical nature. Differences in the arrival time of such signals from a sensory source to different locations in the visual, verbal, etc cortex give rise to different thought patterns that help to clarify phantom limb and blind sight phenomena.

Biochemical and electrical activity, associated with neuronal signals, are observable and measurable at neuronal synapses. Neuronal electric potentials, measurable as alpha, delta, and theta waves by electroencephalograph (EEG) techniques, furnish information on cognitive as well as diseased (epileptic) areas of the brain. Functional magnetic resonance imagings (FMRI), positron emission tomography (PET), as well as optical brain imaging and microscopic needle cranial methods, provide information on areas of cerebral activity that correlate with different mental excitations. In particular, left or right brain activity, associated with analytic or artistic abilities, is linked to cortical areas whose locations vary markedly from individual to individual. Recent magnetic encephalography (MEG) has shown that complex sensory stimuli result in coherent electrical oscillations, but it is unclear as to whether these are indicative of signaling activity within the neuronal network or of mind excitations.

A weeklong patch over one eye of a young kitten causes dendrite atrophy in its visual cortex and permanent retinal blindness in the patched eye. Learning experiments on birds and animals, using invasive techniques, indicate an increase of dendrite numbers in cortical areas associated with learning. Many recent observations appear to show neuronal replication in animals and humans, especially in the young, but also at all ages. Studies of areas of neuronal atrophy caused by cortical injuries and organic disease have shown that mental and physical exercises can invigorate neuron growth in neighboring cortical areas. This plasticity of cerebral neuronal structures is a major reason for mental and physical exercise at all ages.

Fast functional magnetic resonance scans and optical brain imaging have shown that electro-chemical blood activity in specific areas of the cortex is correlated with specific types of thinking and learning. Related neurological research on memory imprinting and forgetting has led to an awareness of important neurotransmitters and receptors, released by electro-chemical processes generated within neuronal synapses. A vast body of research on electro-chemical activities at dendrite and axonal synapses has led to an era of pharmacological chemical development that has had a profound effect on medical treatment of mental disorders. Cell research at the molecular genetic level, a deeper level of neuronal study, offers further promises of correcting many mental and physical diseases.

 

In Summary

 

The developing understanding of the cerebral neuronal network, and of the diversity of dendrite structures involved in higher levels of conceptual reasoning, is one of the exciting open areas of neurobiological research. Current neuronal experiments show that learning and physical exercise engender neuronal plasticity by increasing dendrite and synaptic growth in different areas of the cortex. These observations add credibility to the importance of the nurture side of the “nature versus nurture” debate and thus emphasize the importance of mental exercises that heed the “use it or lose it” paradigm. Increased knowledge of the neuronal structure of the brain and of the nature of mind field excitations points a way for the modern exercise of the Socratic dictum “Know thyself”. The end of the road is not clear but the effort involved in traveling the cognitive science road, which leads to methods for control and flow of thoughts and memories, merits the journey.